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Potent inhibition of scrapie prion replication in cultured cells by bis-acridines
Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds against PrP(Sc) replication in scrapie-infected neuroblastoma cells and now report the improved potency...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC152307/ https://ncbi.nlm.nih.gov/pubmed/12626750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2627988100 |
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