Potent inhibition of scrapie prion replication in cultured cells by bis-acridines

Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds against PrP(Sc) replication in scrapie-infected neuroblastoma cells and now report the improved potency...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	May, Barnaby C. H., Fafarman, Aaron T., Hong, Septima B., Rogers, Michael, Deady, Leslie W., Prusiner, Stanley B., Cohen, Fred E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152307/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12626750/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2627988100
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