Dominant-Negative Inhibition of Prion Formation Diminished by Deletion Mutagenesis of the Prion Protein

Polymorphic basic residues near the C terminus of the prion protein (PrP) in humans and sheep appear to protect against prion disease. In heterozygotes, inhibition of prion formation appears to be dominant negative and has been simulated in cultured cells persistently infected with scrapie prions. T...

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Εκδόθηκε σε:	J Virol
Κύριοι συγγραφείς:	Zulianello, Laurence, Kaneko, Kiyotoshi, Scott, Michael, Erpel, Susanne, Han, Dong, Cohen, Fred E., Prusiner, Stanley B.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 2000
Θέματα:	Structure and Assembly
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111952/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10756050/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.9.4351-4360.2000
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