Dominant-Negative Inhibition of Prion Formation Diminished by Deletion Mutagenesis of the Prion Protein
Polymorphic basic residues near the C terminus of the prion protein (PrP) in humans and sheep appear to protect against prion disease. In heterozygotes, inhibition of prion formation appears to be dominant negative and has been simulated in cultured cells persistently infected with scrapie prions. T...
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| Published in: | J Virol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology (ASM)
2000
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111952/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10756050/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.9.4351-4360.2000 |
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