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Partitioning Conformational Intermediates Between Competing Refolding and Aggregation Pathways: Insights into Transthyretin Amyloid Disease

Amyloid diseases are caused by the aberrant assembly of a protein in the extracellular space. Folded proteins are not amyloidogenic, however the native state is generally in equilibrium with a minor population of unfolded or partially folded aggregation-competent conformers outside of the cell. Unde...

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Main Authors: Wiseman, R. Luke, Powers, Evan T., Kelly, Jeffery W.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2005
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532856/
https://ncbi.nlm.nih.gov/pubmed/16342952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0511484
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