Structural Characterization of Cardiac ex vivo Transthyretin Amyloid: Insight into Transthyretin Misfolding Pathway in vivo

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• Solid-State NMR Studies Reveal Native-like β-sheet Structures in Transthyretin amyloid
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• Pathogenic Mutations Induce Partial Structural Changes in Native β-Sheet Structure of Transthyretin and Accelerate Aggregation
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