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Structural Characterization of Cardiac ex vivo Transthyretin Amyloid: Insight into Transthyretin Misfolding Pathway in vivo

Structural characterization of misfolded protein aggregates is essential to understanding molecular mechanism of protein aggregation associated with various protein misfolding disorders. Here, we report structural analyses of ex vivo transthyretin aggregates extracted from human cardiac tissue. Comp...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Dasari, Anvesh K. R., Hung, Ivan, Michael, Brian, Gan, Zhehong, Kelly, Jeffery W., Connors, Lawreen H., Griffin, Robert G., Lim, Kwang Hun
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306164/
https://ncbi.nlm.nih.gov/pubmed/32338497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00091
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