Structural Changes Associated with Transthyretin Misfolding and Amyloid Formation Revealed by Solution and Solid-State NMR

Elucidation of structural changes involved in protein misfolding and amyloid formation is crucial for unraveling the molecular basis of amyloid formation. Here we report structural analyses of the amyloidogenic intermediate and insoluble aggregates of transthyretin (TTR) using solution and solid-sta...

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Vydáno v:Biochemistry
Hlavní autoři: Lim, Kwang Hun, Dasari, Anvesh K. R., Hung, Ivan, Gan, Zhehong, Kelly, Jeffery W., Wemmer, David E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904294/
https://ncbi.nlm.nih.gov/pubmed/26998642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00164
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