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Structural Changes Associated with Transthyretin Misfolding and Amyloid Formation Revealed by Solution and Solid-State NMR

Elucidation of structural changes involved in protein misfolding and amyloid formation is crucial for unraveling the molecular basis of amyloid formation. Here we report structural analyses of the amyloidogenic intermediate and insoluble aggregates of transthyretin (TTR) using solution and solid-sta...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Lim, Kwang Hun, Dasari, Anvesh K. R., Hung, Ivan, Gan, Zhehong, Kelly, Jeffery W., Wemmer, David E.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904294/
https://ncbi.nlm.nih.gov/pubmed/26998642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00164
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