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Mechanisms of Transthyretin Inhibition of β-Amyloid Aggregation In Vitro
Tissue-specific overexpression of the human systemic amyloid precursor transthyretin (TTR) ameliorates Alzheimer's disease (AD) phenotypes in APP23 mice. TTR–β-amyloid (Aβ) complexes have been isolated from APP23 and some human AD brains. We now show that substoichiometric concentrations of TTR...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Society for Neuroscience
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3858619/ https://ncbi.nlm.nih.gov/pubmed/24336709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2561-13.2013 |
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