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Mechanisms of Transthyretin Inhibition of β-Amyloid Aggregation In Vitro

Tissue-specific overexpression of the human systemic amyloid precursor transthyretin (TTR) ameliorates Alzheimer's disease (AD) phenotypes in APP23 mice. TTR–β-amyloid (Aβ) complexes have been isolated from APP23 and some human AD brains. We now show that substoichiometric concentrations of TTR...

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Detalhes bibliográficos
Main Authors: Li, Xinyi, Zhang, Xin, Ladiwala, Ali Reza A., Du, Deguo, Yadav, Jay K., Tessier, Peter M., Wright, Peter E., Kelly, Jeffery W., Buxbaum, Joel N.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858619/
https://ncbi.nlm.nih.gov/pubmed/24336709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2561-13.2013
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