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Transthyretin variants with improved inhibition of β-amyloid aggregation
Aggregation of β-amyloid (Aβ) is widely believed to cause neuronal dysfunction in Alzheimer's disease. Transthyretin (TTR) binds to Aβ and inhibits its aggregation and neurotoxicity. TTR is a homotetrameric protein, with each monomer containing a short α-helix and two anti-parallel β-sheets. Di...
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| Publicado en: | Protein Eng Des Sel |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4867095/ https://ncbi.nlm.nih.gov/pubmed/27099354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzw008 |
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