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Identification of beta-amyloid-binding sites on transthyretin

Transthyretin (TTR) binds to the Alzheimer-related peptide beta-amyloid (Aβ), and may protect against Aβ-induced neurotoxicity. In this work, the specific domains on TTR involved with binding to Aβ were probed. An array was constructed of peptides derived from overlapping sequences from TTR. Strong...

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Bibliografiske detaljer
Main Authors: Du, Jiali, Cho, Patricia Y., Yang, Dennis T., Murphy, Regina M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530273/
https://ncbi.nlm.nih.gov/pubmed/22670059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzs026
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