Differential modification of Cys10 alters transthyretin's effect on beta-amyloid aggregation and toxicity

Tg2576 mice produce high levels of beta-amyloid (Aβ) and develop amyloid deposits, but lack neurofibrillary tangles and do not suffer the extensive neuronal cell loss characteristic of Alzheimer's disease. Protection from Aβ toxicity has been attributed to up-regulation of transthyretin (TTR),...

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Detalhes bibliográficos
Main Authors: Liu, Lin, Hou, Jie, Du, Jiali, Chumanov, Robert S., Xu, Qingge, Ge, Ying, Johnson, Jeffrey A., Murphy, Regina M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Original articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719498/
https://ncbi.nlm.nih.gov/pubmed/19549717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp025
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