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Differential modification of Cys10 alters transthyretin's effect on beta-amyloid aggregation and toxicity
Tg2576 mice produce high levels of beta-amyloid (Aβ) and develop amyloid deposits, but lack neurofibrillary tangles and do not suffer the extensive neuronal cell loss characteristic of Alzheimer's disease. Protection from Aβ toxicity has been attributed to up-regulation of transthyretin (TTR),...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719498/ https://ncbi.nlm.nih.gov/pubmed/19549717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp025 |
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