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Transthyretin variants with improved inhibition of β-amyloid aggregation
Aggregation of β-amyloid (Aβ) is widely believed to cause neuronal dysfunction in Alzheimer's disease. Transthyretin (TTR) binds to Aβ and inhibits its aggregation and neurotoxicity. TTR is a homotetrameric protein, with each monomer containing a short α-helix and two anti-parallel β-sheets. Di...
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| Udgivet i: | Protein Eng Des Sel |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4867095/ https://ncbi.nlm.nih.gov/pubmed/27099354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzw008 |
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