Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle

Recombinant adeno-associated virus (rAAV) vectors are capable of mediating long-term gene expression following administration to skeletal muscle. In rodent muscle, the vector genomes persist in the nucleus in concatemeric episomal forms. Here, we demonstrate with nonhuman primates that rAAV vectors...

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Detaylı Bibliyografya
Asıl Yazarlar: Penaud-Budloo, Magalie, Le Guiner, Caroline, Nowrouzi, Ali, Toromanoff, Alice, Chérel, Yan, Chenuaud, Pierre, Schmidt, Manfred, von Kalle, Christof, Rolling, Fabienne, Moullier, Philippe, Snyder, Richard O.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2008
Konular:
Gene Delivery
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519600/
https://ncbi.nlm.nih.gov/pubmed/18524821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00649-08
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