Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle

Recombinant adeno-associated virus (rAAV) vectors are capable of mediating long-term gene expression following administration to skeletal muscle. In rodent muscle, the vector genomes persist in the nucleus in concatemeric episomal forms. Here, we demonstrate with nonhuman primates that rAAV vectors...

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Main Authors: Penaud-Budloo, Magalie, Le Guiner, Caroline, Nowrouzi, Ali, Toromanoff, Alice, Chérel, Yan, Chenuaud, Pierre, Schmidt, Manfred, von Kalle, Christof, Rolling, Fabienne, Moullier, Philippe, Snyder, Richard O.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2008
主題:
Gene Delivery
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519600/
https://ncbi.nlm.nih.gov/pubmed/18524821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00649-08
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