Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle

Recombinant adeno-associated virus (rAAV) vectors are capable of mediating long-term gene expression following administration to skeletal muscle. In rodent muscle, the vector genomes persist in the nucleus in concatemeric episomal forms. Here, we demonstrate with nonhuman primates that rAAV vectors...

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Hlavní autoři: Penaud-Budloo, Magalie, Le Guiner, Caroline, Nowrouzi, Ali, Toromanoff, Alice, Chérel, Yan, Chenuaud, Pierre, Schmidt, Manfred, von Kalle, Christof, Rolling, Fabienne, Moullier, Philippe, Snyder, Richard O.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Gene Delivery
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519600/
https://ncbi.nlm.nih.gov/pubmed/18524821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00649-08
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