Adeno-Associated Viral Vector-Mediated Transgene Expression Is Independent of DNA Methylation in Primate Liver and Skeletal Muscle

Recombinant adeno-associated viral (rAAV) vectors can support long-term transgene expression in quiescent tissues. Intramuscular (IM) administration of a single-stranded AAV vector (ssAAV) in the nonhuman primate (NHP) results in a peak protein level at 2–3 months, followed by a decrease over severa...

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Bibliographische Detailangaben
Hauptverfasser: Léger, Adrien, Le Guiner, Caroline, Nickerson, Michael L., McGee Im, Kate, Ferry, Nicolas, Moullier, Philippe, Snyder, Richard O., Penaud-Budloo, Magalie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110818/
https://ncbi.nlm.nih.gov/pubmed/21687632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020881
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