Integration Frequency and Intermolecular Recombination of rAAV Vectors in Non-human Primate Skeletal Muscle and Liver

The comprehensive characterization of recombinant adeno-associated viral (rAAV) integration frequency and persistence for assessing rAAV vector biosafety in gene therapy is severely limited due to the predominance of episomal rAAV vector genomes maintained in vivo. Introducing rAAV insertional stand...

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Библиографические подробности
Главные авторы: Nowrouzi, Ali, Penaud-Budloo, Magalie, Kaeppel, Christine, Appelt, Uwe, Le Guiner, Caroline, Moullier, Philippe, Kalle, Christof von, Snyder, Richard O, Schmidt, Manfred
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369298/
https://ncbi.nlm.nih.gov/pubmed/22453768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.47
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