Integration Frequency and Intermolecular Recombination of rAAV Vectors in Non-human Primate Skeletal Muscle and Liver

The comprehensive characterization of recombinant adeno-associated viral (rAAV) integration frequency and persistence for assessing rAAV vector biosafety in gene therapy is severely limited due to the predominance of episomal rAAV vector genomes maintained in vivo. Introducing rAAV insertional stand...

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Detalhes bibliográficos
Main Authors: Nowrouzi, Ali, Penaud-Budloo, Magalie, Kaeppel, Christine, Appelt, Uwe, Le Guiner, Caroline, Moullier, Philippe, Kalle, Christof von, Snyder, Richard O, Schmidt, Manfred
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369298/
https://ncbi.nlm.nih.gov/pubmed/22453768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.47
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