Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle

Recombinant adeno-associated virus (rAAV) vectors are capable of mediating long-term gene expression following administration to skeletal muscle. In rodent muscle, the vector genomes persist in the nucleus in concatemeric episomal forms. Here, we demonstrate with nonhuman primates that rAAV vectors...

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Detalhes bibliográficos
Main Authors: Penaud-Budloo, Magalie, Le Guiner, Caroline, Nowrouzi, Ali, Toromanoff, Alice, Chérel, Yan, Chenuaud, Pierre, Schmidt, Manfred, von Kalle, Christof, Rolling, Fabienne, Moullier, Philippe, Snyder, Richard O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519600/
https://ncbi.nlm.nih.gov/pubmed/18524821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00649-08
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