Structure and Inhibition of a Quorum Sensing Target from Streptococcus pneumoniae

Streptococcus pneumoniae 5′-methylthioadenosine/S-adenosylhomocysteine hydrolase (MTAN) catalyzes the hydrolytic deadenylation of its substrates to form adenine and 5-methylthioribose or S-ribosylhomocysteine (SRH). MTAN is not found in mammals but is involved in bacterial quorum sensing. MTAN gene...

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Hlavní autoři: Singh, Vipender, Shi, Wuxian, Almo, Steven C., Evans, Gary B., Furneaux, Richard H., Tyler, Peter C., Zheng, Renjian, Schramm, Vern L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517848/
https://ncbi.nlm.nih.gov/pubmed/17059210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061184i
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