BCL6-mediated Attenuation of DNA Damage Sensing Triggers Growth Arrest and Senescence through a p53-dependent Pathway in a Cell Context-dependent Manner

The BCL6 oncogenic transcriptional repressor is required for development of germinal center centroblasts, which undergo simultaneous genetic recombination and massive clonal expansion. Although BCL6 is required for survival of centroblasts, its expression in earlier B-cells is toxic. Understanding t...

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Main Authors: Ranuncolo, Stella Maris, Wang, Ling, Polo, Jose M., Dell'Oso, Tania, Dierov, Jamil, Gaymes, Terry J., Rassool, Feyruz, Carroll, Martin, Melnick, Ari
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504889/
https://ncbi.nlm.nih.gov/pubmed/18524763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803490200
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