BCL6-mediated Attenuation of DNA Damage Sensing Triggers Growth Arrest and Senescence through a p53-dependent Pathway in a Cell Context-dependent Manner

The BCL6 oncogenic transcriptional repressor is required for development of germinal center centroblasts, which undergo simultaneous genetic recombination and massive clonal expansion. Although BCL6 is required for survival of centroblasts, its expression in earlier B-cells is toxic. Understanding t...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Ranuncolo, Stella Maris, Wang, Ling, Polo, Jose M., Dell'Oso, Tania, Dierov, Jamil, Gaymes, Terry J., Rassool, Feyruz, Carroll, Martin, Melnick, Ari
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2008
Aiheet:
Molecular Basis of Cell and Developmental Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504889/
https://ncbi.nlm.nih.gov/pubmed/18524763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803490200
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