Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro‐inflammatory phenotype, thought to contribute to aging and age‐related diseases. Neutrophils have essential roles in inflammatory responses; however, in certain contexts their abundance is associated with a nu...

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Vydáno v:EMBO J
Hlavní autoři: Lagnado, Anthony, Leslie, Jack, Ruchaud‐Sparagano, Marie‐Helene, Victorelli, Stella, Hirsova, Petra, Ogrodnik, Mikolaj, Collins, Amy L, Vizioli, Maria Grazia, Habiballa, Leena, Saretzki, Gabriele, Evans, Shane A, Salmonowicz, Hanna, Hruby, Adam, Geh, Daniel, Pavelko, Kevin D, Dolan, David, Reeves, Helen L, Grellscheid, Sushma, Wilson, Colin H, Pandanaboyana, Sanjay, Doolittle, Madison, von Zglinicki, Thomas, Oakley, Fiona, Gallage, Suchira, Wilson, Caroline L, Birch, Jodie, Carroll, Bernadette, Chapman, James, Heikenwalder, Mathias, Neretti, Nicola, Khosla, Sundeep, Masuda, Claudio Akio, Tchkonia, Tamar, Kirkland, James L, Jurk, Diana, Mann, Derek A, Passos, João F
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090854/
https://ncbi.nlm.nih.gov/pubmed/33764576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106048
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