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Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides

The discovery of ghrelin O-acyltransferase (GOAT) opens the way to the design of drugs that block the attachment of an octanoyl group to the appetite-stimulating peptide hormone ghrelin, potentially preventing obesity. Here, we develop a biochemical assay that uses membranes from insect cells infect...

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Detalhes bibliográficos
Main Authors: Yang, Jing, Zhao, Tong-Jin, Goldstein, Joseph L., Brown, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504781/
https://ncbi.nlm.nih.gov/pubmed/18669668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805353105
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