Ghrelin octanoylation by ghrelin O-acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling

The acylated peptide hormone ghrelin impacts a wide range of physiological processes but is most well known for controlling hunger and metabolic regulation. Ghrelin requires a unique posttranslational modification, serine octanoylation, to bind and activate signalling through its cognate GHS-R1a rec...

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Bibliographic Details
Published in:Open Biol
Main Authors: Davis, Tasha R., Pierce, Mariah R., Novak, Sadie X., Hougland, James L.
Format: Artigo
Language:Inglês
Published: The Royal Society 2021
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316800/
https://ncbi.nlm.nih.gov/pubmed/34315274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.210080
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