The ghrelin O-acyltransferase structure reveals a catalytic channel for transmembrane hormone acylation

Integral membrane proteins represent a large and diverse portion of the proteome and are often recalcitrant to purification, impeding studies essential for understanding protein structure and function. By combining co-evolutionary constraints and computational modeling with biochemical validation th...

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Опубликовано в: :J Biol Chem
Главные авторы: Campaña, Maria B., Irudayanathan, Flaviyan Jerome, Davis, Tasha R., McGovern-Gooch, Kayleigh R., Loftus, Rosemary, Ashkar, Mohammad, Escoffery, Najae, Navarro, Melissa, Sieburg, Michelle A., Nangia, Shikha, Hougland, James L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2019
Предметы:
Accelerated Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768652/
https://ncbi.nlm.nih.gov/pubmed/31413115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.009749
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