Expansion of Protein Farnesyltransferase Specificity Using “Tunable” Active Site Interactions: DEVELOPMENT OF BIOENGINEERED PRENYLATION PATHWAYS

Por Hougland, James L., Gangopadhyay, Soumyashree A., Fierke, Carol A.
Publicado em 2012

Functional Identification of Catalytic Metal Ion Binding Sites within RNA

Por Hougland, James L, Kravchuk, Alexander V, Herschlag, Daniel, Piccirilli, Joseph A
Publicado em 2005

Identification of a Novel Class of Farnesylation Targets by Structure-Based Modeling of Binding Specificity

Por London, Nir, Lamphear, Corissa L., Hougland, James L., Fierke, Carol A., Schueler-Furman, Ora
Publicado em 2011

Context-dependent substrate recognition by protein farnesyltransferase

Por Hougland, James L., Lamphear, Corissa L., Scott, Sarah A., Gibbs, Richard A., Fierke, Carol A.
Publicado em 2009

Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates

Por Krzysiak, Amanda J., Aditya, Animesh V., Hougland, James L., Fierke, Carol A., Gibbs, Richard A.
Publicado em 2009

Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities

Por Hougland, James L., Hicks, Katherine A., Hartman, Heather L., Kelly, Rebekah A., Watt, Terry J., Fierke, Carol A.
Publicado em 2009

Simultaneous Site-Specific Dual Protein Labeling Using Protein Prenyltransferases

Por Zhang, Yi, Blanden, Melanie J., Sudheer, Ch., Gangopadhyay, Soumyashree A., Rashidian, Mohammad, Hougland, James L., Distefano, Mark D.
Publicado no Bioconjug Chem (2015)

Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice

Por Wellman, Martin K., Patterson, Zachary R., MacKay, Harry, Darling, Joseph E., Mani, Bharath K., Zigman, Jeffrey M., Hougland, James L., Abizaid, Alfonso
Publicado no Front Endocrinol (Lausanne) (2015)

Synthetic triterpenoid inhibition of human ghrelin O-acyltransferase: Involvement of a functionally required cysteine provides mechanistic insight into ghrelin acylation

Por McGovern-Gooch, Kayleigh R., Mahajani, Nivedita S., Garagozzo, Ariana, Schramm, Anthony J., Hannah, Lauren G., Sieburg, Michelle A., Chisholm, John D., Hougland, James L.
Publicado no Biochemistry (2017)