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Identification of a Novel Class of Farnesylation Targets by Structure-Based Modeling of Binding Specificity
Farnesylation is an important post-translational modification catalyzed by farnesyltransferase (FTase). Until recently it was believed that a C-terminal CaaX motif is required for farnesylation, but recent experiments have revealed larger substrate diversity. In this study, we propose a general stru...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3188499/ https://ncbi.nlm.nih.gov/pubmed/21998565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002170 |
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