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In-silico and in-vitro elucidation of BH3 binding specificity towards Bcl-2
Interactions between Bcl-2 like proteins and BH3 domains play a key role in the regulation of apoptosis. Despite the overall structural similarity of their interaction with helical BH3 domains, Bcl-2 like proteins exhibit an intricate spectrum of binding specificities whose underlying basis is not w...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711574/ https://ncbi.nlm.nih.gov/pubmed/22702834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3003567 |
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