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Structure based re-design of the binding specificity of anti-apoptotic Bcl-x(L)
Many native proteins are multi-specific and interact with numerous partners, which can confound analysis of their functions. Protein design provides a potential route to generating synthetic variants of native proteins with more selective binding profiles. Re-designed proteins could be used as resea...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557458/ https://ncbi.nlm.nih.gov/pubmed/23154169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.11.009 |
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