Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells

[Image: see text] Mcl-1 is overexpressed in many cancers and can confer resistance to cell-death signaling in refractory disease. Molecules that specifically inhibit Mcl-1 hold potential for diagnosing and disrupting Mcl-1-dependent cell survival. We selected three peptides from a yeast-surface disp...

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Bibliographic Details
Main Authors: Foight, Glenna Wink, Ryan, Jeremy A., Gullá, Stefano V., Letai, Anthony, Keating, Amy E.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168798/
https://ncbi.nlm.nih.gov/pubmed/25052212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500340w
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