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Molecular Determinants of the Binding Specificity of BH3 Ligands to BclXL Apoptotic Repressor
BclXL serves as an apoptotic repressor by virtue of its ability to recognize and bind to BH3 domains found within a diverse array of pro-apoptotic regulators. Herein, we investigate the molecular basis of the specificity of the binding of pro-apoptotic BH3 ligands to BclXL. Our data reveal that whil...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3968242/ https://ncbi.nlm.nih.gov/pubmed/24114183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.22419 |
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