Heat-Induced Fibrillation of BclXL Apoptotic Repressor

The BclXL apoptotic repressor bears the propensity to associate into megadalton oligomers in solution, particularly under acidic pH. Herein, using various biophysical methods, we analyze the effect of temperature on the oligomerization of BclXL. Our data show that BclXL undergoes irreversible aggreg...

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Détails bibliographiques
Auteurs principaux: Bhat, Vikas, Olenick, Max B., Schuchardt, Brett J., Mikles, David C., Deegan, Brian J., McDonald, Caleb B., Seldeen, Kenneth L., Kurouski, Dmitry, Faridi, Mohd Hafeez, Shareef, Mohammed M., Gupta, Vineet, Lednev, Igor K., Farooq, Amjad
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706518/
https://ncbi.nlm.nih.gov/pubmed/23714425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2013.04.002
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