Acidic pH Promotes Oligomerization and Membrane Insertion of the BclXL Apoptotic Repressor

Solution pH is believed to serve as an intricate regulatory switch in the induction of apoptosis central to embryonic development and cellular homeostasis. Herein, using an array of biophysical techniques, we provide evidence that acidic pH promotes the assembly of BclXL apoptotic repressor into a m...

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Main Authors: Bhat, Vikas, Kurouski, Dmitry, Olenick, Max B., McDonald, Caleb B., Mikles, David C., Deegan, Brian J., Seldeen, Kenneth L., Lednev, Igor K., Farooq, Amjad
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483416/
https://ncbi.nlm.nih.gov/pubmed/22960132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2012.08.009
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