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Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates
Proteins bearing a CaaL sequence are typically geranylgeranylated to enable their proper localization and function. We found that many of the dansyl-GCaaL peptides representing mammalian CaaL proteins can be farnesylated by FTase. This result may have important implications for prenylated protein bi...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922960/ https://ncbi.nlm.nih.gov/pubmed/20005705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.11.011 |
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