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Analogs of farnsyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase

Attempts to identify the prenyl-proteome of cells or changes in prenylation following drug treatment have used “clickable” alkyne-modified analogs of the lipid substrates farnesyl- and geranylgeranyl-diphosphate (FPP and GGPP). We characterized the reactivity of four alkyne-containing analogs of FPP...

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Vydáno v:	Bioorg Med Chem Lett
Hlavní autoři:	Jennings, Benjamin C., Danowitz, Amy M., Wang, Yen-Chih, Gibbs, Richard A., Distefano, Mark D., Fierke, Carol A.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2015
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4747817/ https://ncbi.nlm.nih.gov/pubmed/26803203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.12.079
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Analogs of farnsyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase

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