Analogs of farnsyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase

Attempts to identify the prenyl-proteome of cells or changes in prenylation following drug treatment have used “clickable” alkyne-modified analogs of the lipid substrates farnesyl- and geranylgeranyl-diphosphate (FPP and GGPP). We characterized the reactivity of four alkyne-containing analogs of FPP...

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Publicado en:Bioorg Med Chem Lett
Autores principales: Jennings, Benjamin C., Danowitz, Amy M., Wang, Yen-Chih, Gibbs, Richard A., Distefano, Mark D., Fierke, Carol A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747817/
https://ncbi.nlm.nih.gov/pubmed/26803203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.12.079
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