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Analogs of farnsyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase
Attempts to identify the prenyl-proteome of cells or changes in prenylation following drug treatment have used “clickable” alkyne-modified analogs of the lipid substrates farnesyl- and geranylgeranyl-diphosphate (FPP and GGPP). We characterized the reactivity of four alkyne-containing analogs of FPP...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4747817/ https://ncbi.nlm.nih.gov/pubmed/26803203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.12.079 |
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