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Farnesyl Diphosphate Analogues with Aryl Moieties are Efficient Alternate Substrates for Protein Farnesyltransferase

Farnesylation is an important post-translational modification essential for proper localization and function of many proteins. Transfer of the farnesyl group from farnesyl diphosphate (FPP) to proteins is catalyzed by protein farnesyltransferase (FTase). We employed a library of FPP analogues with a...

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主要な著者: Subramanian, Thangaiah, Pais, June E., Liu, Suxia, Troutman, Jerry M., Suzuki, Yuta, Subramanian, Karunai Leela, Fierke, Carol, Andres, Douglas A., Spielmann, H. Peter
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562418/
https://ncbi.nlm.nih.gov/pubmed/22989235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3011362
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