Farnesyl Diphosphate Analogues with Aryl Moieties are Efficient Alternate Substrates for Protein Farnesyltransferase

Farnesylation is an important post-translational modification essential for proper localization and function of many proteins. Transfer of the farnesyl group from farnesyl diphosphate (FPP) to proteins is catalyzed by protein farnesyltransferase (FTase). We employed a library of FPP analogues with a...

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Detalhes bibliográficos
Main Authors: Subramanian, Thangaiah, Pais, June E., Liu, Suxia, Troutman, Jerry M., Suzuki, Yuta, Subramanian, Karunai Leela, Fierke, Carol, Andres, Douglas A., Spielmann, H. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562418/
https://ncbi.nlm.nih.gov/pubmed/22989235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3011362
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