Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

Ghrelin O-acyltransferase (GOAT) attaches octanoate to proghrelin, which is processed to ghrelin, an octanoylated peptide hormone that stimulates release of growth hormone (GH) from pituitary cells. Elimination of the gene encoding ghrelin or its receptor produces only mild phenotypes in mice. Thus,...

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Detalhes bibliográficos
Main Authors: Zhao, Tong-Jin, Liang, Guosheng, Li, Robert Lin, Xie, Xuefen, Sleeman, Mark W., Murphy, Andrew J., Valenzuela, David M., Yancopoulos, George D., Goldstein, Joseph L., Brown, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867684/
https://ncbi.nlm.nih.gov/pubmed/20231469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002271107
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