The GOAT-Ghrelin System Is Not Essential for Hypoglycemia Prevention during Prolonged Calorie Restriction

OBJECTIVE: Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance. Using a unique set of four different genetic loss-of-function models for the GOAT/ghrelin/growth hormone secretagog...

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Main Authors: Yi, Chun-Xia, Heppner, Kristy M., Kirchner, Henriette, Tong, Jenny, Bielohuby, Maximillian, Gaylinn, Bruce D., Müller, Timo D., Bartley, Erin, Davis, Harold W., Zhao, Yongmei, Joseph, Anupama, Kruthaupt, Traci, Ottaway, Nickki, Kabra, Dhiraj, Habegger, Kirk M., Benoit, Stephen C., Bidlingmaier, Martin, Thorner, Michael O., Perez-Tilve, Diego, Tschöp, Matthias H., Pfluger, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283719/
https://ncbi.nlm.nih.gov/pubmed/22363801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032100
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