Acylation Type Determines Ghrelin's Effects on Energy Homeostasis in Rodents

Ghrelin is a gastrointestinal polypeptide that acts through the ghrelin receptor (GHSR) to promote food intake and increase adiposity. Activation of GHSR requires the presence of a fatty-acid (FA) side chain on amino acid residue serine 3 of the ghrelin molecule. However, little is known about the r...

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Hauptverfasser: Heppner, Kristy M., Chaudhary, Nilika, Müller, Timo D., Kirchner, Henriette, Habegger, Kirk M., Ottaway, Nickki, Smiley, David L., DiMarchi, Richard, Hofmann, Susanna M., Woods, Stephen C., Sivertsen, Bjørn, Holst, Birgitte, Pfluger, Paul T., Perez-Tilve, Diego, Tschöp, Matthias H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2012
Schlagworte:
Energy Balance-Obesity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512022/
https://ncbi.nlm.nih.gov/pubmed/22865372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1194
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