Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors

We have identified 1H-benzylindole analogues as a novel series of human immunodeficiency virus (HIV) integrase inhibitors with antiretroviral activities against different strains of HIV type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strain MAC(251) [SIV(MAC(251))]. Molecular modeling and s...

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Detalhes bibliográficos
Main Authors: Hombrouck, Anneleen, Van Remoortel, Barbara, Michiels, Martine, Noppe, Wim, Christ, Frauke, Eneroth, Anders, Sahlberg, Britt Louise, Benkestock, Kurt, Vrang, Lotta, Johansson, Nils Gunnar, Barreca, Maria Letizia, De Luca, Laura, Ferro, Stefania, Chimirri, Alba, Debyser, Zeger, Witvrouw, Myriam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493095/
https://ncbi.nlm.nih.gov/pubmed/18541726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00210-08
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