Mutations in Human Immunodeficiency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137

To gain further insight into the understanding of the antiviral resistance patterns and mechanisms of the integrase strand transfer inhibitor L-870,810, the prototypical naphthyridine analogue, we passaged the human immunodeficiency virus type 1 strain HIV-1(III(B)) in cell culture in the presence o...

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Autores principales: Hombrouck, Anneleen, Voet, Arnout, Van Remoortel, Barbara, Desadeleer, Christel, De Maeyer, Marc, Debyser, Zeger, Witvrouw, Myriam
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2415791/
https://ncbi.nlm.nih.gov/pubmed/18378713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00911-07
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