Development of Resistance against Diketo Derivatives of Human Immunodeficiency Virus Type 1 by Progressive Accumulation of Integrase Mutations

The diketo acid L-708,906 has been reported to be a selective inhibitor of the strand transfer step of the human immunodeficiency virus type 1 (HIV-1) integration process (D. Hazuda, P. Felock, M. Witmer, A. Wolfe, K. Stillmock, J. A. Grobler, A. Espeseth, L. Gabryelski, W. Schleif, C. Blau, and M....

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Detalhes bibliográficos
Main Authors: Fikkert, Valery, Van Maele, Bénédicte, Vercammen, Jo, Hantson, Anke, Van Remoortel, Barbara, Michiels, Martine, Gurnari, Cristina, Pannecouque, Christophe, De Maeyer, Marc, Engelborghs, Yves, De Clercq, Erik, Debyser, Zeger, Witvrouw, Myriam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC229256/
https://ncbi.nlm.nih.gov/pubmed/14557631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.21.11459-11470.2003
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