The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

The positive transcription elongation factor b (P-TEFb) (CDK9/cyclin T (CycT)) promotes mRNA transcriptional elongation through phosphorylation of elongation repressors and RNA polymerase II. To understand the regulation of a transcriptional CDK by its cognate cyclin, we have determined the structur...

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Autores principales: Baumli, Sonja, Lolli, Graziano, Lowe, Edward D, Troiani, Sonia, Rusconi, Luisa, Bullock, Alex N, Debreczeni, Judit É, Knapp, Stefan, Johnson, Louise N
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2486423/
https://ncbi.nlm.nih.gov/pubmed/18566585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.121
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