The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

Cyclin D-Cdk4/6 and cyclin A/E-Cdk2 are suggested to be involved in phosphorylation of the retinoblastoma protein (pRB) during the G1/S transition of the cell cycle. However, it is unclear why several Cdks are needed and how they are different from one another. We found that the consensus amino acid...

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Main Authors: Kitagawa, M, Higashi, H, Jung, H K, Suzuki-Takahashi, I, Ikeda, M, Tamai, K, Kato, J, Segawa, K, Yoshida, E, Nishimura, S, Taya, Y
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC452531/
https://ncbi.nlm.nih.gov/pubmed/9003781
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