Chargement en cours...
Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation
The HIV trans-activator Tat recruits the host transcription elongation factor P-TEFb to stimulate proviral transcription. Phosphorylation of Thr-186 on the activation loop (T-loop) of cyclin-dependent kinase 9 (CDK9) is essential for its kinase activity and assembly of CDK9 and cyclin T1 (CycT1) to...
Enregistré dans:
| Publié dans: | J Biol Chem |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2018
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6028954/ https://ncbi.nlm.nih.gov/pubmed/29743242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001347 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|