T-loop phosphorylation stabilizes the CDK7–cyclin H–MAT1 complex in vivo and regulates its CTD kinase activity

Cyclin-dependent kinase (CDK)7–cyclin H, the CDK-activating kinase (CAK) and TFIIH-associated kinase in metazoans can be activated in vitro through T-loop phosphorylation or binding to the RING finger protein MAT1. Although the two mechanisms can operate independently, we show that in a physiologica...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Larochelle, Stéphane, Chen, Jian, Knights, Ronald, Pandur, Judit, Morcillo, Patrick, Erdjument-Bromage, Hediye, Tempst, Paul, Suter, Beat, Fisher, Robert P.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125544/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447116/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.14.3749
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