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T-loop phosphorylation stabilizes the CDK7–cyclin H–MAT1 complex in vivo and regulates its CTD kinase activity

Cyclin-dependent kinase (CDK)7–cyclin H, the CDK-activating kinase (CAK) and TFIIH-associated kinase in metazoans can be activated in vitro through T-loop phosphorylation or binding to the RING finger protein MAT1. Although the two mechanisms can operate independently, we show that in a physiologica...

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Udgivet i:EMBO J
Principais autores: Larochelle, Stéphane, Chen, Jian, Knights, Ronald, Pandur, Judit, Morcillo, Patrick, Erdjument-Bromage, Hediye, Tempst, Paul, Suter, Beat, Fisher, Robert P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125544/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447116/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.14.3749
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